Emotional feeling in patients suffering from amyotrophic lateral sclerosis.
Identifieur interne : 000956 ( Main/Exploration ); précédent : 000955; suivant : 000957Emotional feeling in patients suffering from amyotrophic lateral sclerosis.
Auteurs : Johanna Unglik [France] ; Catherine Bungener [France] ; Daniel Delgadillo [France] ; François Salachas [France] ; Pierre François Pradat [France] ; Gaëlle Bruneteau [France] ; Timothée Lenglet [France] ; Nadine Le Forestier [France] ; Philippe Couratier [France] ; Yannick Vacher [France] ; Lucette Lacomblez [France]Source :
- Geriatrie et psychologie neuropsychiatrie du vieillissement [ 2115-7863 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- psychologie : Anxiété, Sclérose latérale amyotrophique.
- complications : Adulte d'âge moyen, Anxiété, Apathie, Cognition, Femelle, Humains, Mâle, Sujet âgé, Tests neuropsychologiques, Émotions.
English descriptors
- KwdEn :
- MESH :
- complications : Anxiety.
- psychology : Amyotrophic Lateral Sclerosis, Anxiety.
- Aged, Apathy, Cognition, Emotions, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
OBJECTIVE
Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving motor neurons of the cerebral cortex, brain stem and spinal cord. Besides the motor signs, cognitive disorders and apathy may be present and may impact the survival time. These elements are therefore to be taken into consideration for medical care because they can influence the disease evolution. The literature shows low psychopathological disorders in this population despite its poor prognosis. The main objective of this study is to explore the emotional feeling in apathetic and non-apathetic patients in relation to their anxiety and depressive symptoms.
METHODS
We included 152 patients at the day hospital for the follow-up of their illness, with an average age of 61±12.2 years. All filled the following self-administered questionnaires: EPN-31 (emotional feeling), HADS (for anxiety and depressive symptoms) and the Marin's apathy evaluation scale. Most of the patients (n=110) had also a cognitive assessment with the ALS-CBS scale.
RESULTS
42% of patients could be considered as apathetic and they felt both positive and negative emotions whose frequency was related to the presence and intensity of anxiety and depressive symptoms. The only significant differences were that apathetic and anxious patients experienced more negative emotions including sadness, shame and anger than non-apathetic and anxious patients. Apathy was negatively correlated with cognitive functioning and survival time.
CONCLUSIONS
These results highlighted the negative impact that apathy seemed to have on the evolution of this disease. However, apathetic patients didn't show emotional blunting and were able to name and feel positive and negative emotions; and even feel more negative emotions than non-apathetic patients when they were anxious. A better understanding of apathetic and no apathetic patients' emotional feelings should lead to a more personalized care for the ALS patients.
DOI: 10.1684/pnv.2018.0762
PubMed: 30355543
Affiliations:
Links toward previous steps (curation, corpus...)
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type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bruneteau, Gaelle" sort="Bruneteau, Gaelle" uniqKey="Bruneteau G" first="Gaëlle" last="Bruneteau">Gaëlle Bruneteau</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, Institut du cerveau et de la moelle épinière, ICM, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, Institut du cerveau et de la moelle épinière, ICM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lenglet, Timothee" sort="Lenglet, Timothee" uniqKey="Lenglet T" first="Timothée" last="Lenglet">Timothée Lenglet</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurophysiologie clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurophysiologie clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Le Forestier, Nadine" sort="Le Forestier, Nadine" uniqKey="Le Forestier N" first="Nadine" last="Le Forestier">Nadine Le Forestier</name><affiliation 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region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Vacher, Yannick" sort="Vacher, Yannick" uniqKey="Vacher Y" first="Yannick" last="Vacher">Yannick Vacher</name><affiliation wicri:level="3"><nlm:affiliation>Département de la recherche clinique et du développement, AP-HP, Hôpital Saint-Louis, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de la recherche clinique et du développement, AP-HP, Hôpital Saint-Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30355543</idno><idno type="pmid">30355543</idno><idno type="doi">10.1684/pnv.2018.0762</idno><idno type="wicri:Area/Main/Corpus">000677</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" 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de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Bungener, Catherine" sort="Bungener, Catherine" uniqKey="Bungener C" first="Catherine" last="Bungener">Catherine Bungener</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Delgadillo, Daniel" sort="Delgadillo, Daniel" uniqKey="Delgadillo D" first="Daniel" last="Delgadillo">Daniel Delgadillo</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Salachas, Francois" sort="Salachas, Francois" uniqKey="Salachas F" first="François" last="Salachas">François Salachas</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pradat, Pierre Francois" sort="Pradat, Pierre Francois" uniqKey="Pradat P" first="Pierre François" last="Pradat">Pierre François Pradat</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), Sorbonne Universités, UPMC Université Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bruneteau, Gaelle" sort="Bruneteau, Gaelle" uniqKey="Bruneteau G" first="Gaëlle" last="Bruneteau">Gaëlle Bruneteau</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, Institut du cerveau et de la moelle épinière, ICM, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, Institut du cerveau et de la moelle épinière, ICM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lenglet, Timothee" sort="Lenglet, Timothee" uniqKey="Lenglet T" first="Timothée" last="Lenglet">Timothée Lenglet</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurophysiologie clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurophysiologie clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Le Forestier, Nadine" sort="Le Forestier, Nadine" uniqKey="Le Forestier N" first="Nadine" last="Le Forestier">Nadine Le Forestier</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Couratier, Philippe" sort="Couratier, Philippe" uniqKey="Couratier P" first="Philippe" last="Couratier">Philippe Couratier</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, CHU, Hôpital Dupuytren, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, CHU, Hôpital Dupuytren, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Vacher, Yannick" sort="Vacher, Yannick" uniqKey="Vacher Y" first="Yannick" last="Vacher">Yannick Vacher</name><affiliation wicri:level="3"><nlm:affiliation>Département de la recherche clinique et du développement, AP-HP, Hôpital Saint-Louis, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de la recherche clinique et du développement, AP-HP, Hôpital Saint-Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name><affiliation wicri:level="3"><nlm:affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Geriatrie et psychologie neuropsychiatrie du vieillissement</title><idno type="eISSN">2115-7863</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Amyotrophic Lateral Sclerosis (psychology)</term><term>Anxiety (complications)</term><term>Anxiety (psychology)</term><term>Apathy (MeSH)</term><term>Cognition (MeSH)</term><term>Emotions (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neuropsychological Tests (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Anxiété (complications)</term><term>Anxiété (psychologie)</term><term>Apathie (MeSH)</term><term>Cognition (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Sclérose latérale amyotrophique (psychologie)</term><term>Sujet âgé (MeSH)</term><term>Tests neuropsychologiques (MeSH)</term><term>Émotions (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Anxiété</term><term>Sclérose latérale amyotrophique</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term><term>Anxiety</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Apathy</term><term>Cognition</term><term>Emotions</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Anxiété</term><term>Apathie</term><term>Cognition</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Tests neuropsychologiques</term><term>Émotions</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving motor neurons of the cerebral cortex, brain stem and spinal cord. Besides the motor signs, cognitive disorders and apathy may be present and may impact the survival time. These elements are therefore to be taken into consideration for medical care because they can influence the disease evolution. The literature shows low psychopathological disorders in this population despite its poor prognosis. The main objective of this study is to explore the emotional feeling in apathetic and non-apathetic patients in relation to their anxiety and depressive symptoms.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We included 152 patients at the day hospital for the follow-up of their illness, with an average age of 61±12.2 years. All filled the following self-administered questionnaires: EPN-31 (emotional feeling), HADS (for anxiety and depressive symptoms) and the Marin's apathy evaluation scale. Most of the patients (n=110) had also a cognitive assessment with the ALS-CBS scale.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>42% of patients could be considered as apathetic and they felt both positive and negative emotions whose frequency was related to the presence and intensity of anxiety and depressive symptoms. The only significant differences were that apathetic and anxious patients experienced more negative emotions including sadness, shame and anger than non-apathetic and anxious patients. Apathy was negatively correlated with cognitive functioning and survival time.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>These results highlighted the negative impact that apathy seemed to have on the evolution of this disease. However, apathetic patients didn't show emotional blunting and were able to name and feel positive and negative emotions; and even feel more negative emotions than non-apathetic patients when they were anxious. A better understanding of apathetic and no apathetic patients' emotional feelings should lead to a more personalized care for the ALS patients.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30355543</PMID><DateCompleted><Year>2019</Year><Month>04</Month><Day>01</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2115-7863</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>4</Issue><PubDate><Year>2018</Year><Month>Dec</Month><Day>01</Day></PubDate></JournalIssue><Title>Geriatrie et psychologie neuropsychiatrie du vieillissement</Title><ISOAbbreviation>Geriatr Psychol Neuropsychiatr Vieil</ISOAbbreviation></Journal><ArticleTitle>Emotional feeling in patients suffering from amyotrophic lateral sclerosis.</ArticleTitle><Pagination><MedlinePgn>414-422</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1684/pnv.2018.0762</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving motor neurons of the cerebral cortex, brain stem and spinal cord. Besides the motor signs, cognitive disorders and apathy may be present and may impact the survival time. These elements are therefore to be taken into consideration for medical care because they can influence the disease evolution. The literature shows low psychopathological disorders in this population despite its poor prognosis. The main objective of this study is to explore the emotional feeling in apathetic and non-apathetic patients in relation to their anxiety and depressive symptoms.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We included 152 patients at the day hospital for the follow-up of their illness, with an average age of 61±12.2 years. All filled the following self-administered questionnaires: EPN-31 (emotional feeling), HADS (for anxiety and depressive symptoms) and the Marin's apathy evaluation scale. Most of the patients (n=110) had also a cognitive assessment with the ALS-CBS scale.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">42% of patients could be considered as apathetic and they felt both positive and negative emotions whose frequency was related to the presence and intensity of anxiety and depressive symptoms. The only significant differences were that apathetic and anxious patients experienced more negative emotions including sadness, shame and anger than non-apathetic and anxious patients. Apathy was negatively correlated with cognitive functioning and survival time.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results highlighted the negative impact that apathy seemed to have on the evolution of this disease. However, apathetic patients didn't show emotional blunting and were able to name and feel positive and negative emotions; and even feel more negative emotions than non-apathetic patients when they were anxious. A better understanding of apathetic and no apathetic patients' emotional feelings should lead to a more personalized care for the ALS patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Unglik</LastName><ForeName>Johanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France, Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bungener</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire de psychopathologie et processus de santé - EA 4057, Sorbonne-Paris-Cité, Université Paris-Descartes, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delgadillo</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salachas</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pradat</LastName><ForeName>Pierre François</ForeName><Initials>PF</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), Sorbonne Universités, UPMC Université Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruneteau</LastName><ForeName>Gaëlle</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, Institut du cerveau et de la moelle épinière, ICM, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lenglet</LastName><ForeName>Timothée</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Département de neurophysiologie clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Forestier</LastName><ForeName>Nadine</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couratier</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Département de neurologie, CHU, Hôpital Dupuytren, Limoges, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vacher</LastName><ForeName>Yannick</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Département de la recherche clinique et du développement, AP-HP, Hôpital Saint-Louis, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lacomblez</LastName><ForeName>Lucette</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Émotions ressenties chez des patients atteints de sclérose latérale amyotrophique.</VernacularTitle></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Geriatr Psychol Neuropsychiatr Vieil</MedlineTA><NlmUniqueID>101553404</NlmUniqueID><ISSNLinking>2115-7863</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Geriatr Psychol Neuropsychiatr Vieil. 2018 Dec 1;16(4):398</RefSource><PMID Version="1">30563800</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000690" MajorTopicYN="N">Amyotrophic Lateral Sclerosis</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057565" MajorTopicYN="N">Apathy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003071" MajorTopicYN="N">Cognition</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004644" MajorTopicYN="Y">Emotions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">amyotrophic lateral sclerosis</Keyword><Keyword MajorTopicYN="N">anxiety</Keyword><Keyword MajorTopicYN="N">apathy</Keyword><Keyword MajorTopicYN="N">depressive symptoms</Keyword><Keyword MajorTopicYN="N">emotion</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30355543</ArticleId><ArticleId IdType="pii">pnv.2018.0762</ArticleId><ArticleId IdType="doi">10.1684/pnv.2018.0762</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Limousin</li><li>Nouvelle-Aquitaine</li><li>Île-de-France</li></region><settlement><li>Limoges</li><li>Paris</li></settlement><orgName><li>Université Paris-Descartes</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Unglik, Johanna" sort="Unglik, Johanna" uniqKey="Unglik J" first="Johanna" last="Unglik">Johanna Unglik</name></region><name sortKey="Bruneteau, Gaelle" sort="Bruneteau, Gaelle" uniqKey="Bruneteau G" first="Gaëlle" last="Bruneteau">Gaëlle Bruneteau</name><name sortKey="Bungener, Catherine" sort="Bungener, Catherine" uniqKey="Bungener C" first="Catherine" last="Bungener">Catherine Bungener</name><name sortKey="Couratier, Philippe" sort="Couratier, Philippe" uniqKey="Couratier P" first="Philippe" last="Couratier">Philippe Couratier</name><name sortKey="Delgadillo, Daniel" sort="Delgadillo, Daniel" uniqKey="Delgadillo D" first="Daniel" last="Delgadillo">Daniel Delgadillo</name><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name><name sortKey="Le Forestier, Nadine" sort="Le Forestier, Nadine" uniqKey="Le Forestier N" first="Nadine" last="Le Forestier">Nadine Le Forestier</name><name sortKey="Lenglet, Timothee" sort="Lenglet, Timothee" uniqKey="Lenglet T" first="Timothée" last="Lenglet">Timothée Lenglet</name><name sortKey="Pradat, Pierre Francois" sort="Pradat, Pierre Francois" uniqKey="Pradat P" first="Pierre François" last="Pradat">Pierre François Pradat</name><name sortKey="Salachas, Francois" sort="Salachas, Francois" uniqKey="Salachas F" first="François" last="Salachas">François Salachas</name><name sortKey="Vacher, Yannick" sort="Vacher, Yannick" uniqKey="Vacher Y" first="Yannick" last="Vacher">Yannick Vacher</name></country></tree></affiliations></record>Pour 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